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Leptin concentration in children with juvenile idiopathic arthritis

Izabela Maciejewska-Paszek, Elżbieta Grochowska-Niedworok, Andrzej Siwiec

  • 1Department of Health Promotion and Community Nursing, Medical University of Silesia, Katowice, Poland; Department of Nephrology/ENDO MSW Hospital Katowice, Poland. tirzyniec@sum.edu.pl.

Endokrynologia Polska
|October 13, 2015
PubMed

Insights

Juvenile idiopathic arthritis (JIA) in children is linked to altered leptin levels, particularly in those with lower BMI. Shorter disease duration in JIA patients correlates with greater leptin variability relative to BMI.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Endocrinology

Background:

  • Leptin plays a crucial role in regulating the immune system.
  • Juvenile idiopathic arthritis (JIA) is a chronic childhood joint disease impacting motor function.

Purpose of the Study:

  • To investigate leptin concentration (LEP) and its relationship with body mass index (BMI) in children with JIA.
  • To compare LEP and BMI in JIA patients with varying disease durations against healthy controls.

Main Methods:

  • Analyzed LEP, BMI, haematocrit, haemoglobin, white blood cell counts (WBC, LYMPH), erythrocyte sedimentation rate (ESR), and ANA Hep-2 antibodies in 42 children with JIA and 28 healthy children.
  • Subdivided JIA group into longer disease duration (IA, n=22) and shorter disease duration (IB, n=20).

Main Results:

  • Children with JIA exhibited higher LYMPH and ESR levels compared to healthy controls.
  • JIA patients with BMI < 23 kg/m2 showed reduced LEP compared to controls (p=0.04).
  • A significant relationship was observed between JIA, LEP, and BMI, with shorter disease duration correlating with higher LEP diversification per BMI unit.

Conclusions:

  • Children with JIA and BMI < 23 kg/m2 have lower leptin concentrations than healthy children.
  • Higher leptin concentration variability per BMI unit is observed in JIA patients with shorter disease duration compared to healthy controls.
Abstract

Keywords:
BMIjuvenile idiopathic arthritisleptin

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