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Environments of hematopoiesis and B-lymphopoiesis in foetal liver

Katja Kajikhina1, Motokazu Tsuneto2, Fritz Melchers3

  • 1Max Planck Fellow Research Group on "Lymphocyte Development", Max Planck Institute for Infection Biology, Berlin, Germany.

Clinical and Experimental Rheumatology
|October 13, 2015
PubMed

In human and murine embryonic development, haematopoiesis and B-lymphopoiesis show stepwise differentiation from pluripotent haematopoietic stem cells and multipotent progenitors, over lineage-restricted lymphoid and myeloid progenitors to B-lineage committed precursors and finally differentiated pro/preB cells. This wave of differentiation is spatially and temporally organised by the surrounding, mostly non-haematopoietic cell niches. We review here recent developments and our current contributions on the research on blood cell development.

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