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Updated: Apr 1, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Reversible Assembly of a Supramolecular Cage Linked by Boron-Nitrogen Dative Bonds
1Universität Würzburg, Institut für Organische Chemie and, Center for Nanosystems Chemistry (CNC), Am Hubland, 97074 Würzburg (Germany).
Abstract:
Boron-nitrogen dative bonds provide a suitable motif for reversible, yet strong and directed interactions, leading to the highly efficient self-assembly of small organic building blocks into supramolecular cage structures. A bipyramidal [2+3] assembly, as the first example of a supramolecular cage mediated by BN dative bonds that exists as a discrete species in solution, is quantitatively obtained from a tribenzotriquinacene-based trisboronate ester and 1,4-diazabicyclo[2.2.2]octane. Thermodynamic equilibria of cage formation are investigated by isothermal titration calorimetry and fully reversible cage opening can be observed at elevated temperatures.
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