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Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans

Daniel Espes1,2, Mats Martinell3, Hanna Liljebäck4

  • 1Department of Medical Cell Biology, Uppsala University, BMC, Husargatan 3, Box 571, Uppsala, SE-75123, Sweden. Daniel.Espes@mcb.uu.se.

Current Diabetes Reports
|October 14, 2015
PubMed

Insights

Betatrophin, a hormone, shows promise for treating type 2 diabetes by stimulating beta cell proliferation. This review explores its potential role in humans, offering hope for a cure.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Research

Background:

  • Type 2 diabetes prevalence is rising globally, with current treatments lacking a cure.
  • Increasing beta cell mass is a potential curative strategy for type 2 diabetes.
  • Limited data exists on human beta cell proliferation compared to rodents.

Purpose of the Study:

  • To review existing clinical data on the hormone betatrophin.
  • To discuss the potential role of betatrophin in human diabetes treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on betatrophin.
  • Analysis of betatrophin's effects on beta cell proliferation and glucose metabolism.

Main Results:

  • Betatrophin demonstrated potent beta cell proliferation in mice.
  • Preclinical findings suggest betatrophin counteracts insulin resistance-induced glucose intolerance.

Conclusions:

  • Betatrophin represents a promising new target for diabetes drug development.
  • Further clinical research is needed to validate betatrophin's efficacy and safety in humans.
Keywords:
Beta cell proliferationBetatrophinDiabetesHumansIsletLiver

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