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Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids
Published on: September 1, 2023
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[Generation of functional organs from pluripotent stem cells].
Tatsuyuki Miyamoto1, Hiromitsu Nakauchi
1Division of Stem Cell Therapy Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 14, 2015
Summary
Scientists created functional organs in animals using stem cells. This breakthrough in organogenesis could lead to generating patient-specific organs for transplantation in the future.
Area of Science:
- Stem cell biology
- Developmental biology
- Organogenesis
Context:
- The concept of the stem cell niche, initially identified in bone marrow for hematopoietic stem cells (HSCs), has been extended to organ development.
- Successful HSC transplantation relies on the niche microenvironment and myeloablative pretreatment to clear the niche.
Purpose:
- To investigate the potential of an "organ niche" concept for generating organs via blastocyst complementation.
- To demonstrate organogenesis using primary stem cells (PSCs) in genetically modified embryos lacking specific organ development.
Summary:
- Researchers proved the principle of organogenesis from xenogeneic PSCs by generating a functional rat pancreas in pancreatogenesis-disabled mouse embryos.
- This approach was successfully replicated in pigs, where pancreatogenesis-disabled pig embryos complemented with wild-type pig PSCs developed normal pancreata and survived to adulthood.
Impact:
- This study establishes a critical proof-of-concept for generating functional organs from PSCs in large animals.
- The findings represent a significant advancement toward the future generation of human cells, tissues, and organs from patient-specific PSCs.
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