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Neutron therapy for nonresectable radioresistant tumors
1Midwest Institute for Neutron Therapy at Fermilab, Batavia, Ill 60510.
Archives of Surgery (Chicago, Ill. : 1960)
|March 1, 1989
Summary
High-energy fast neutron beams effectively treat radioresistant tumors. This therapy offers significant remission and improved survival for advanced, nonresectable cancers, including sarcomas and adenocarcinomas.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Locally advanced, nonresectable tumors often exhibit radioresistance to conventional therapies.
- External irradiation with high-energy fast neutron beams presents a potential therapeutic option.
Purpose of the Study:
- To evaluate the efficacy of fast neutron therapy in managing radioresistant, nonresectable malignant tumors.
- To explore the biological rationale for using fast neutrons in cancer treatment.
Main Methods:
- Utilized external irradiation with high-energy fast neutron beams.
- Analyzed treatment outcomes including local control, complete response, and survival rates.
- Described the biological mechanisms of radioresistance and neutron therapy.
Main Results:
- Achieved long-term local control in various malignant tumors like sarcomas and adenocarcinomas.
- Reported complete response and remission rates of 50-70% in osteogenic sarcomas, soft-tissue sarcomas, melanomas, and alimentary tract adenocarcinomas.
- Demonstrated high remission rates (70-90%) and improved survival in malignant salivary gland tumors and prostate carcinoma.
Conclusions:
- Fast neutron therapy is a valuable adjunct for managing nonresectable malignant tumors resistant to conventional treatments.
- Neutron irradiation shows significant efficacy in achieving remission and improving survival, even in advanced stages of specific cancers.