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Variant Philadelphia translocations in chronic myeloid leukemia: A report of five cases
Vijaya V Mysorekar1, Murali Subramanian, Nalini Kilara
1Department of Pathology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India.
Abstract:
The t (9;22)(q34;q11) translocation is found in about 90% of the chronic myeloid leukemia patients. About 5-10% of these patients have complex variant translocations involving a third chromosome in addition to chromosomes 9 and 22. We describe five male patients in the chronic myeloid leukemia-chronic phase, with rare variant Philadelphia translocations. All of them had the BCR-ABL fusion gene and responded well to treatment with imatinib mesylate. All the patients are on regular follow-up.
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