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Published on: February 17, 2012
A case report of peritoneal malignant mesothelioma presenting as primary ovarian mass
Rakesh Kapoor1, Philip George Kuttikat, Kim Vaiphei
1Department of Radiation Oncology, Regional Cancer Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Abstract:
Malignant mesotheliomas are aggressive neoplasms arising from mesothelial cells lining the body cavities. Malignant peritoneal mesothelioma (MPM) account for about one-third of the cases. Though the ovarian involvement may be seen in the background of a diffuse peritoneal involvement, the presentation of MPM as a primary ovarian mass is rare. Here we present such a case who underwent surgery but had residual progressive lesion. She received further chemotherapy resulting in a complete response and is disease free for almost a year.
Insights
Malignant peritoneal mesothelioma (MPM) rarely presents as a primary ovarian mass. This case study shows successful chemotherapy treatment leading to a complete response and sustained remission.
Area of Science:
- Oncology
- Pathology
- Gynecologic Oncology
Background:
- Malignant mesotheliomas are aggressive neoplasms originating from mesothelial cells.
- Malignant peritoneal mesothelioma (MPM) constitutes approximately one-third of mesothelioma cases.
- Ovarian involvement in MPM typically occurs secondary to diffuse peritoneal disease.
Observation:
- This report details a rare instance of MPM presenting as a primary ovarian mass.
- The patient underwent surgical intervention, which resulted in a residual progressive lesion.
- Subsequent chemotherapy led to a complete response.
Findings:
- The patient achieved a complete response to chemotherapy.
- The patient has remained disease-free for nearly one year post-treatment.
- This case highlights an unusual presentation of MPM.
Implications:
- This case underscores the importance of considering rare presentations of MPM in gynecologic oncology.
- Effective chemotherapy regimens can achieve durable remission in select MPM cases.
- Further research into primary ovarian MPM is warranted to optimize diagnostic and therapeutic strategies.
