Related Experiment Video
Updated: Apr 1, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
Over ten thousand cases and counting: acidbase.org is serving the critical care community
Paul W G Elbers1, Niels Van Regenmortel, Rainer Gatz
1Department of Intensive Care Medicine; Research VUmc Intensive Care; Institute for Cardiovascular Research Vrije Universiteit (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, Netherlands. p.elbers@vumc.nl.
Abstract:
Acidbase.org has been serving the critical care community for over a decade. The backbone of this online resource consists of Peter Stewart's original text "How to understand Acid-Base" which is freely available to everyone. In addition, Stewart's Textbook of Acid Base, which puts the theory in today's clinical context is available for purchase from the website. However, many intensivists use acidbase.org on a daily basis for its educational content and in particular for its analysis module. This review provides an overview of the history of the website, a tutorial and descriptive statistics of over 10,000 queries submitted to the analysis module.
Related Concept Videos
Bronsted-Lowry Acids and Bases
Acid-Base Balance
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
Diagnosing Acidosis and Alkalosis
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
Renal Regulation of Acid-Base Balance
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
Disorders of Acid-Base Balance
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Acid–Base Equilibria: Activity-Based Definition of pH
In solutions of very low ionic strength—for example, pure water—the...

