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Published on: December 17, 2014
Young Patients With Diabetes Have Decreased Cerebrovascular Reactivity Under Hypercapneic Conditions
Virginia W Lin1, Yuri Brosgol1, Peter Homel2
1Center for Brain and Behavior, Maimonides Infants and Children's Hospital of Brooklyn, Brooklyn, New York.
Objective:
Adult diabetic patients have an abnormal cerebrovascular response to hypercapnia, but there are few studies focused on diabetes mellitus type 1 and cerebral blood flow in pediatric or adolescent patients. We hypothesize that young patients with diabetes exhibit a different response to hypercapnia than normal control counterparts.
Methods:
Using transcranial Doppler techniques, we compared young diabetic patients with healthy controls by measuring cerebral blood velocity before and during carbon dioxide challenge.
Results:
Subjects with diabetes had decreased cerebral blood velocity reactivity when compared with the control group (P = 0.005).
Conclusion:
Our results suggest cerebrovascular dysfunction in diabetic patients beginning at an early age. The possibility of long-term implications for cerebrovascular disease demonstrates the need for further studies in the pediatric and adolescent diabetic population to better understand this prevalent condition.
