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Published on: July 7, 2020
Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria
Ji-Young Lee1, Myung-Jin Choi1, Hyeon Jin Choi1
1Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Abstract:
Colistin-resistant mutants were obtained from 17 colistin-susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. The stability of colistin resistance in these mutants was investigated. Three of four colistin-resistant P. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of A. baumannii and E. coli. No susceptible revertants were obtained from K. pneumoniae mutants.
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