Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Karyotyping01:17

Karyotyping

70.1K
Overview
70.1K
Karyotyping01:17

Karyotyping

12.0K
12.0K
Meiosis I01:49

Meiosis I

221.9K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
221.9K
Nondisjunction01:29

Nondisjunction

83.5K
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
83.5K
Nondisjunction01:21

Nondisjunction

5.8K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
5.8K
Nondisjunction01:29

Nondisjunction

10.0K
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New variant in PLP1 gene associated with X-linked spastic paraplegia type 2: First report of a family in Colombia

Biomedica : revista del Instituto Nacional de Salud·2026
Same author

NLRP3 inflammasome activation in the placenta during SARS-CoV-2 infection.

Placenta·2025
Same author

Hearing loss in patients with Morquio A syndrome: A scoping review.

Medicine·2025
Same author

Phenotype-Genotype Correlation in Morquio A Syndrome: Protocol for a Meta-Analysis.

JMIR research protocols·2024
Same author

Fragile X syndrome in the largest world clustering. I. Genetic epidemiology and founder effect outline.

American journal of medical genetics. Part A·2024
Same author

Fragile X Syndrome in children.

Colombia medica (Cali, Colombia)·2023

Related Experiment Video

Updated: Apr 1, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
09:39

Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Published on: December 4, 2021

3.6K

[Trisomy 18 syndrome: A case report].

Wilmar Saldarriaga1, Heidy Rengifo-Miranda2, Julián Ramírez-Cheyne3

  • 1Ginecólogo y obstetra, Magíster en Ciencias Básicas Medicas, Embriología y Genética, Profesor titular, Escuela de Ciencias Básicas Médicas, Universidad del Valle, Cali, Colombia.

Revista Chilena De Pediatria
|October 14, 2015
PubMed
Summary

Trisomy 18 syndrome, a genetic disorder, typically has a high infant mortality rate. This case highlights a rare long-term survivor with unique oral cavity features, expanding knowledge of the condition's phenotype.

Keywords:
Edward's syndromeFull trisomy 18SobrevidaSurvivalSíndrome de EdwardsSíndrome de trisomía 18Síndrome de trisomía 18 completoTrisomy 18

More Related Videos

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

2.7K
Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
11:54

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

9.9K

Related Experiment Videos

Last Updated: Apr 1, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
09:39

Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Published on: December 4, 2021

3.6K
Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

2.7K
Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
11:54

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

9.9K

Area of Science:

  • Genetics
  • Pediatrics
  • Medical Case Reports

Background:

  • Trisomy 18 syndrome (Edwards syndrome) results from an extra chromosome 18.
  • It affects approximately 1 in 6,000 to 8,000 live births.
  • High neonatal and infant mortality rates are characteristic, with few survivors beyond five years.

Observation:

  • A 7-year-old female with trisomy 18 presented with significant growth deficiency, psychomotor retardation, and cognitive disability.
  • Clinical features included dysmorphic facies, feeding difficulties, hearing loss, ataxia, and cerebellar hypoplasia.
  • Unique oral findings included a dome-shaped palate, macroglossia, and absence of specific teeth with delayed eruption.

Findings:

  • Karyotype analysis confirmed 47XX+18 in all metaphases.
  • The patient exhibited a complex phenotype including severe developmental delays and specific anatomical anomalies.
  • Novel oral cavity manifestations, including dental anomalies, were documented.

Implications:

  • This case expands the understanding of the trisomy 18 phenotype in long-term survivors.
  • The documented oral findings provide new information for clinicians managing these patients.
  • Further research is needed to establish the full spectrum of trisomy 18 in older children.