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Contrast Induced Nephropathy and Long-term Renal Decline After Percutaneous Transluminal Angioplasty for Symptomatic

T A Sigterman1, A G Krasznai1, M G Snoeijs1

  • 1Atrium Medical Center Parkstad Heerlen, Heerlen, The Netherlands.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|October 14, 2015
PubMed

Insights

Contrast induced nephropathy (CIN) affects 13% of patients undergoing endovascular procedures for peripheral arterial disease (PAD). CIN is linked to long-term kidney function decline, cardiovascular events, and mortality.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Peripheral arterial disease (PAD) treatment often involves endovascular procedures.
  • Iodinated contrast media used in these procedures can lead to contrast-induced nephropathy (CIN).

Purpose of the Study:

  • To determine the incidence of CIN following endovascular PAD interventions.
  • To investigate the association between CIN and long-term kidney function, cardiovascular events, and mortality.

Main Methods:

  • Prospective observational cohort study.
  • Inclusion of consecutive patients with symptomatic PAD (Rutherford classification II-VI) undergoing endovascular procedures.
  • Definition of CIN as a >25% increase in serum creatinine from baseline at 5 days post-intervention.

Main Results:

  • 13% of 337 patients developed CIN.
  • Patients with CIN experienced a greater reduction in estimated glomerular filtration rate (eGFR) at one year compared to those without.
  • CIN was independently associated with a significant long-term eGFR reduction and increased risk of cardiovascular events and mortality.

Conclusions:

  • Contrast-induced nephropathy (CIN) is a frequent complication of endovascular procedures for PAD.
  • CIN significantly impacts long-term renal function and increases the risk of adverse cardiovascular outcomes and mortality.
Abstract

Keywords:
Cardiovascular eventsContrast induced nephropathyEndovascular interventionsMortalityPeripheral arterial diseaseRenal decline

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