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Updated: Apr 1, 2026

Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

Single-cell epigenomics: techniques and emerging applications.

Omer Schwartzman^1,2,3, Amos Tanay³

¹Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Nature Reviews. Genetics

|October 14, 2015

Summary

This summary is machine-generated.

Single-cell epigenomics analyzes DNA methylation and chromatin accessibility in individual cells. These advanced methods reveal cellular diversity and plasticity in stem cells and cancer research.

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Area of Science:

Genomics
Molecular Biology
Cell Biology

Background:

Epigenomics studies genomic modifications to understand cellular identity and function.
Current bulk methods average epigenomic features, limiting insights into complex tissues.
Growing interest in single-cell resolution for epigenetics in heterogeneous systems.

Purpose of the Study:

To review emerging single-cell epigenomic techniques.
To highlight their application in understanding cellular plasticity and diversity.

Main Methods:

Review of single-cell methods for DNA methylation capture.
Review of single-cell methods for chromatin accessibility analysis.
Review of single-cell methods for histone modifications, chromosome conformation, and replication dynamics.

Main Results:

Single-cell epigenomics enables detailed analysis of epigenomic landscapes at the individual cell level.
These methods capture diverse epigenetic marks including DNA methylation and chromatin accessibility.
Emerging techniques cover histone modifications, chromosome conformation, and replication timing.

Conclusions:

Single-cell epigenomics is a rapidly advancing field.
These techniques are powerful tools for studying cellular plasticity and diversity.
Applications include stem cell biology and cancer research.