Related Experiment Video
Updated: Apr 1, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors
Jing Zhang1, Qingyi Yang1, Jason B Cross1
1Cubist Pharmaceuticals Inc. , Lexington, Massachusetts 02421, United States.
Abstract:
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the discovery of azaindole ureas as a novel class of bacterial gyrase B inhibitors and detail the story of their evolution from a de novo design hit based on structure-based drug design. These inhibitors show potent minimum inhibitory concentrations against fluoroquinolone resistant MRSA and other Gram-positive bacteria.
More Related Videos
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Inhibitors of Bacterial DNA Synthesis
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Inhibitors of Gram-positive Cell Wall Synthesis
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Gene Regulation in Microbial Communities: Quorum Sensing

