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Related Experiment Video

Updated: Apr 1, 2026

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

In situ Endothelialization: Bioengineering Considerations to Translation.

Jun Hon Pang¹, Yasmin Farhatnia¹, Fatemeh Godarzi¹

¹Centre for Nanotechnology & Regenerative Medicine, Division of Surgery & Interventional Science, University College London (UCL), London, UK.

Small (Weinheim an Der Bergstrasse, Germany)

|October 14, 2015

Summary

Improving cardiovascular implants requires a healthy endothelium. This review explores biomaterial strategies for in situ endothelialization using endothelial progenitor cells (EPCs) to enhance implant performance and clinical translation.

Keywords:

Genous Stent cardiovascular implants cell capture endothelial progenitors endothelialization interventional cardiology

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Area of Science:

Biomaterials Science
Regenerative Medicine
Cardiovascular Engineering

Background:

Cardiovascular implant patency is limited by endothelialization.
In vitro pre-seeding of endothelial cells is impractical for clinical use.
In situ endothelialization offers a promising alternative for blood-contacting surfaces.

Purpose of the Study:

To review biomaterial strategies for enhancing in situ endothelialization.
To discuss bio-/nanoengineering considerations for controlling cell behavior.
To provide insights from clinical trials for future translation.

Main Methods:

Literature review of biomaterial strategies for in situ endothelialization.
Analysis of bio-/nanoengineering techniques for cell control.
Examination of clinical trial outcomes related to endothelialization.

Main Results:

In situ endothelialization using endothelial progenitor cells (EPCs) is a key strategy.
Biomolecule immobilization and physical patterning are methods to control cell behavior.
Clinical trial lessons highlight the need for careful design and consideration.

Conclusions:

Biomaterial strategies are crucial for successful in situ endothelialization.
Optimizing bio-/nanoengineering is essential for controlling cell integration.
Addressing clinical insights will facilitate the translation of these advanced biomaterials.