Related Experiment Video
Updated: Apr 1, 2026
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis
Lingxie Song1, Lian Meng1, Jifeng Peng1
1Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
Aim:
Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer.
Methods:
Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis.
Results:
A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer.
Conclusion:
Notch1 over-expression indicated aggressive biological behaviors.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
03:14Notch Signaling Pathway
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...