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Related Concept Videos

Adhesion01:14

Adhesion

45.5K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Cell Adhesion in Plants01:14

Cell Adhesion in Plants

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
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Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
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Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
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Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins

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Adhesion with a Sumo.

Michel Labouesse1

  • 1Laboratoire de Biologie du Développement, CNRS-UMR7622, Institut de Biologie Paris-Seine, Université Pierre et Marie Curie, Sorbonne Universités, 75005 Paris, France.

Developmental Cell
|October 14, 2015
PubMed
Summary
This summary is machine-generated.

Sumoylation and desumoylation of E-cadherin regulate adherens junctions assembly. This study reveals how these post-translational modifications control E-cadherin localization, impacting epithelial development and cancer.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Adherens junctions (AJs) are vital for epithelial tissue integrity and development.
  • Dysregulation of AJs is implicated in tumorigenesis.
  • Understanding AJ assembly and disassembly mechanisms is crucial.

Purpose of the Study:

  • To investigate the role of post-translational modifications in E-cadherin localization to AJs.
  • To elucidate the mechanisms controlling adherens junction dynamics.

Main Methods:

  • Focuses on the study by Tsur et al. (2015).
  • Investigates sumoylation and desumoylation processes.
  • Examines E-cadherin recruitment to adherens junctions.

Main Results:

  • Sumoylation and desumoylation of E-cadherin directly influence its recruitment to AJs.
  • These modifications are key regulators of adherens junction dynamics.
  • Provides a novel mechanism for controlling E-cadherin localization.

Conclusions:

  • Post-translational modification of E-cadherin by sumoylation/desumoylation is a critical regulator of adherens junction assembly.
  • This finding offers new insights into epithelial tissue development and cancer progression.