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Updated: Apr 1, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
PPARγ: Welcoming the New Kid on the CML Stem Cell Block
Beth Apsel Winger1, Neil P Shah2
1Department of Pediatric Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94143, USA.
Abstract:
Recently, chronic myeloid leukemia (CML) patients already responding to treatment showed improved molecular responses with pioglitazone, presumably through PPARγ activation and CML stem cell eradication. Given data demonstrating deepening responses and successful treatment discontinuation with current therapy, the necessity for new therapies targeting CML stem cells to achieve cure is unclear.
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