Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Safety and efficacy of tofacitinib for the treatment of patients with juvenile idiopathic arthritis: preliminary results of an open-label, long-term extension study.

Annals of the rheumatic diseases·2024

Same author

One-year outcomes of same-day-discharge robot-assisted radical prostatectomy.

BJU international·2024

Same author

Robotic-assisted radical cystectomy with cutaneous ureterostomies: a contemporary multicenter analysis.

World journal of urology·2024

Same author

How can we reduce morbidity after robot-assisted radical cystectomy with intracorporeal neobladder? A report on postoperative complications by the European Association of Urology Robotic Urology Section Scientific Working Group.

BJU international·2024

Same author

Corrigendum to "European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines" [Eur. Urol. 85 (2024) 17-31].

European urology·2024

Same author

Complications of immuno-oncology care: what urologist should know.

BJU international·2024

Same journal

Palliative Therapy for Liver and Biliary Neoplasms.

Hematology/oncology clinics of North America·2026

Same journal

Ablative Therapies for Liver Tumors.

Hematology/oncology clinics of North America·2026

Same journal

Pathology of Liver and Biliary Neoplasms.

Hematology/oncology clinics of North America·2026

Same journal

Minimally Invasive Surgery for Liver and Biliary Tract Neoplasms.

Hematology/oncology clinics of North America·2026

Same journal

Surgical Considerations for Primary Liver Neoplasms.

Hematology/oncology clinics of North America·2026

Same journal

Systemic Therapy for Biliary and Liver Neoplasms: Chemotherapy and Immunotherapy.

Hematology/oncology clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 1, 2026

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation

Published on: December 26, 2013

Macrophage Activation Syndrome.

Angelo Ravelli¹, Sergio Davì², Francesca Minoia²

¹Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Head, Center of Rheumatology, University of Genoa and G. Gaslini Institute, via G. Gaslini 5, Genoa 16147, Italy.

Hematology/Oncology Clinics of North America

|October 14, 2015

Summary

This summary is machine-generated.

Macrophage activation syndrome (MAS), a severe complication of rheumatic diseases like systemic juvenile idiopathic arthritis, is better understood. Interleukin-1 inhibitors show promise as adjunctive therapy for difficult MAS cases.

Keywords:

Hemophagocytic lymphohistiocytosis Hemophagocytic syndrome Interleukin-1 inhibitors Macrophage activation syndrome Proinflammatory cytokines Systemic juvenile idiopathic arthritis

More Related Videos

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Published on: October 31, 2017

Related Experiment Videos

Last Updated: Apr 1, 2026

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation

Published on: December 26, 2013

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Published on: October 31, 2017

Area of Science:

Rheumatology
Immunology
Pediatric Rheumatology

Background:

Macrophage activation syndrome (MAS) is a critical, life-threatening condition.
It frequently complicates systemic juvenile idiopathic arthritis (sJIA).

Purpose of the Study:

To review recent advances in understanding MAS pathophysiology.
To discuss new classification criteria for MAS.
To evaluate potential therapeutic strategies for MAS.

Main Methods:

Literature review of recent research on MAS.
Analysis of new diagnostic and classification criteria.
Assessment of current and emerging treatment options.

Main Results:

Significant progress has been made in elucidating the pathophysiology of MAS.
Novel classification criteria for MAS have been established.
Interleukin-1 inhibitors are emerging as a potential adjunctive treatment.

Conclusions:

MAS understanding has advanced, aiding diagnosis and management.
Interleukin-1 inhibitors offer a promising therapeutic avenue for refractory MAS.
Further research is needed to clarify the role of cytokine blockers in MAS management.