Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.9K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.9K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

862
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
862
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

2.6K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.6K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.1K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.1K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.8K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.8K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

665
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
665

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: "First experiments with ultrashort, circularly polarized soft x-ray pulses at FLASH2" [Struct. Dyn. <b>12</b>, 034301 (2025)].

Structural dynamics (Melville, N.Y.)·2026
Same author

Emergent Chaos-Like Dynamics of Spin-Orbit-Torque-Driven Magnetic Transitions.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Time-Domain Extreme-Ultraviolet Diffuse Scattering Spectroscopy of Nanoscale Surface Phonons.

Physical review letters·2026
Same author

Energy Spectrum of Ultrahigh-Energy Cosmic Rays across Declinations -90° to +44.8° as Measured at the Pierre Auger Observatory.

Physical review letters·2026
Same author

First experiments with ultrashort, circularly polarized soft x-ray pulses at FLASH2.

Structural dynamics (Melville, N.Y.)·2025
Same author

Search for the Anomalous Events Detected by ANITA Using the Pierre Auger Observatory.

Physical review letters·2025

Related Experiment Video

Updated: Apr 1, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.7K

Hypercholesterolemia as a risk factor for depressive disorder?

A De Bem1, D Engel2, J de Oliveira2

  • 1Campus Universitário Trindade (Centro de Ciências Biológica), Departamento de Bioquímica, Florianópolis - Brazil..

Free Radical Biology & Medicine
|October 14, 2015
PubMed
Summary

Hypercholesterolemia in mice induced depressive-like behaviors, including reduced grooming and increased immobility. These changes were linked to brain alterations and reversed by fluoxetine, suggesting a link between high cholesterol and depression.

More Related Videos

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.3K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.9K

Related Experiment Videos

Last Updated: Apr 1, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.7K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.3K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.9K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Genetics

Background:

  • Epidemiological studies link elevated plasma cholesterol to depression.
  • Hypercholesterolemia is increasingly associated with cognitive and brain function impairments.
  • Low-density lipoprotein receptor knockout (LDLr(-/-)) mice, a model for familial hypercholesterolemia, exhibit memory deficits and mitochondrial dysfunction.

Purpose of the Study:

  • To investigate the impact of hypercholesterolemia on depressive-like behaviors in LDLr(-/-) mice.
  • To explore the underlying neurobiological mechanisms, including monoamine oxidase activity, hemeoxygenase-1 levels, and blood-brain barrier permeability.

Main Methods:

  • Adult wild-type and LDLr(-/-) mice were assessed using the splash test and forced swimming test.
  • Monoamine oxidase activity and hemeoxygenase-1 mRNA levels were measured in the hippocampus and cerebral cortex.
  • Blood-brain barrier permeability was evaluated via AQP-4 immunofluorescence staining.

Main Results:

  • LDLr(-/-) mice displayed reduced grooming and increased immobility, indicative of depressive-like behavior.
  • Fluoxetine treatment reversed these behavioral changes.
  • Hypercholesterolemia was associated with increased monoamine oxidase A activity, decreased hemeoxygenase-1 mRNA, and elevated blood-brain barrier permeability in the hippocampus.

Conclusions:

  • Hypercholesterolemia can induce brain alterations that contribute to depressive disorders.
  • These findings highlight a potential biological link between high cholesterol levels and the pathophysiology of depression.
  • Targeting cholesterol metabolism may offer novel therapeutic strategies for depression.