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In vivo observation of the pH alternation in mitochondria for various external stimuli
Lixia Cao1, Zhensheng Zhao1, Tao Zhang1
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
Abstract:
The pH of mitochondria (pHm) has a close relationship with many biological processes. Here we developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value, which has excellent tolerance to environmental change. And Mito-pH-1 has been used for the first time to monitor the change of pHm under temperature and H2O2 stimuli in living cells.
