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Is the CARD8 rs2043211 polymorphism associated with susceptibility to Crohn's disease? A meta-analysis

Zi-Teng Zhang1, Xiu-Juan Ma1, Ying Zong1

  • 1a Department of Health Toxicology , Second Military Medical University , Shanghai , China and.

Autoimmunity
|October 15, 2015
PubMed

Insights

The CARD8 rs2043211 gene variant may offer protection against specific types of Crohn's disease (CD), such as ileal or stenotic CD. This meta-analysis found no overall association with CD susceptibility in the general population.

Area of Science:

  • Genetics
  • Gastroenterology
  • Immunology

Background:

  • Conflicting evidence exists regarding the association between CARD8 gene polymorphism rs2043211 and Crohn's disease (CD) susceptibility.
  • Understanding genetic factors influencing CD pathogenesis is crucial for developing targeted therapies.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between CARD8 rs2043211 polymorphism and Crohn's disease (CD) risk.
  • To explore potential ethnic and disease-subtype specific associations.

Main Methods:

  • Systematic literature search up to July 2014 across multiple databases.
  • Inclusion of six eligible articles comprising eight studies.
  • Meta-analysis using odds ratios (ORs) and 95% confidence intervals (CIs) with heterogeneity and publication bias assessments.

Main Results:

  • No significant association between CARD8 rs2043211 and overall CD risk or in the Caucasian subgroup (additive model).
  • Significant association found in subgroup analyses for ileal CD (OR=0.83, 95% CI=0.70-0.98) and stenotic or fistulizing CD (OR=0.81, 95% CI=0.72-0.92) in the additive model.
  • The mutant-type rs2043211 polymorphism may confer a protective effect in specific CD subtypes.

Conclusions:

  • Crohn's disease (CD) likely involves diverse pathogenic mechanisms and clinical presentations.
  • The CARD8 rs2043211 polymorphism may play a protective role in ileal, stenotic, or fistulizing forms of CD.
  • Further research is warranted to elucidate the specific roles of genetic variants in CD subtypes.

Keywords:
CARD8 rs2043211Crohn’s diseasemeta-analysis

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