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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Apr 1, 2026

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons

Published on: August 26, 2021

Modeling ALS and FTD with iPSC-derived neurons.

Sebum Lee¹, Eric J Huang²

¹Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0502, United States.

|October 15, 2015

Summary

Patient-specific stem cells offer new ways to study amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTD), showing promise for drug discovery despite current limitations.

Keywords:

Amyotrophic lateral sclerosis (ALS)Frontotemporal dementia (FTD)Frontotemporal lobar degeneration (FTLD)Induced pluripotent stem cells (iPSCs)

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Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

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Published on: November 9, 2020

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Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

Area of Science:

Neuroscience
Genetics
Stem Cell Biology

Background:

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTD) are increasingly viewed as part of a disease spectrum.
Existing animal models for ALS and FTD have limitations in reflecting human neurodegenerative processes.

Purpose of the Study:

To review the use of induced pluripotent stem cells (iPSCs) in modeling ALS and FTD.
To highlight the potential of iPSC-derived neurons for understanding disease mechanisms and drug discovery.

Main Methods:

Summarizing studies utilizing patient-specific iPSC-derived neurons.
Analyzing the capabilities and limitations of iPSC-based models for ALS and FTD.

Main Results:

iPSC-derived neurons can recapitulate key features of ALS and FTD.
These models show significant potential for advancing drug discovery efforts.

Conclusions:

iPSC-derived neurons represent a powerful tool for modeling ALS and FTD.
Further improvements are needed to overcome existing caveats and enhance their efficacy as disease models.