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Updated: Mar 31, 2026

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
Published on: April 19, 2017
Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile
Giulia Ganzetti1, Anna Campanati, E Molinelli
1Dermatologic Clinic, Polytechnic University of Marche Region, Ancona, Via Conca, 71, 60126 Ancona, Italy. giulia.ganzetti@alice.it.
Abstract:
Biologic treatments have modified the therapeutic armamentarium in the treatment of many dermatological and non- dermatological diseases and data on literature have widely focused on the efficacy and safety of TNF-alpha inhibitors in psoriasis. Although the etiopathogenesis has not completely elucidated, inflammation appears the lait motif unifying the immune-pathogenesis of diverse skin disease, as atopic dermatitis, alopecia areata and hidradenitis suppurativa. Actually, data on the off-label use of biologics in cutaneous immune-mediated inflammatory diseases are scarce and restricted to anecdotal cases and case series. The present review aims to evidence the major off- label use of TNF-alpha inhibitors in dermatology.
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