Recent development of ionic liquid stationary phases for liquid chromatography
Xianzhe Shi1, Lizhen Qiao1, Guowang Xu1
1Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Journal of Chromatography. A
|October 15, 2015
Summary
Ionic liquids immobilized on supports create versatile stationary phases for liquid chromatography. These phases offer multi-mode separation mechanisms, enhancing analytical chemistry applications.
Area of Science:
- Analytical Chemistry
- Chromatography
Background:
- Ionic liquids possess unique physicochemical properties, leading to broad applications in analytical chemistry.
- Immobilization of ionic liquids onto supports like silica and monoliths is a key strategy for developing advanced chromatographic stationary phases.
Purpose of the Study:
- To review the immobilized patterns and types of ionic liquid stationary phases.
- To summarize the retention mechanisms and applications of these phases over the last five years.
Main Methods:
- Covalent bonding of various ionic liquids onto supporting materials.
- Characterization of the resulting ionic liquid stationary phases.
Main Results:
- Ionic liquid stationary phases exhibit multi-mode separation mechanisms, including hydrophobic, hydrophilic, hydrogen bonding, anion exchange, π-π, and dipole-dipole interactions.
- These phases are applicable in diverse chromatographic modes such as ion-exchange, reversed-phase liquid chromatography (RPLC), normal-phase liquid chromatography (NPLC), and hydrophilic interaction liquid chromatography (HILIC).
Conclusions:
- Immobilized ionic liquid stationary phases offer versatile separation capabilities for various compound classes.
- Recent advancements focus on diverse immobilization strategies and applications in chromatography.
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