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Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
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Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of
Jin Hu1, Guilin Wang1, Xinyu Liu1
1Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.
Abstract:
Genetic fusion of elastin-like polypeptide (ELP) to the C-terminus of interferon alpha (IFN) generates a well-defined IFN-ELP fusion protein with high yield and well-retained bioactivity. The fusion protein significantly enhances pharmacokinetics, tumor accumulation, and antitumor efficacy of interferon alpha in a murine cancer model.
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