Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.3K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are Japanese Older Adults Rejuvenating? Changes in Health-Related Measures Among Older Community Dwellers in the Last Decade.

Rejuvenation research·2020
Same author

Association of heterogeneous MYCN amplification with clinical features, biological characteristics and outcomes in neuroblastoma: A report from the Children's Oncology Group.

European journal of cancer (Oxford, England : 1990)·2020
Same author

The Role of the Clinical Laboratory in the Diagnosis of Neuroblastoma.

The journal of applied laboratory medicine·2020
Same author

MYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma.

Cell death & disease·2020
Same author

Engagement in Lifestyle Activities is Associated with Increased Alzheimer's Disease-Associated Cortical Thickness and Cognitive Performance in Older Adults.

Journal of clinical medicine·2020
Same author

The Effect of a Multicomponent Dual-Task Exercise on Cortical Thickness in Older Adults with Cognitive Decline: A Randomized Controlled Trial.

Journal of clinical medicine·2020

Related Experiment Video

Updated: Mar 31, 2026

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
15:57

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

17.3K

Age-related changes in prefrontal oxygenation during memory encoding and retrieval.

Kazuki Uemura1, Takehiko Doi2,3, Hiroyuki Shimada2

  • 1Institute of Innovation for Future Society, Nagoya University, Nagoya, Japan.

Geriatrics & Gerontology International
|October 15, 2015
PubMed
Summary

Older adults experience reduced prefrontal cortex oxygenation during memory tasks, impacting memory performance. Near-infrared spectroscopy reveals age-related changes in cerebral blood flow crucial for cognitive function.

Keywords:
agingbraincognitive declinedementiamemorynear-infrared spectroscopy

More Related Videos

Using Fiberless, Wearable fNIRS to Monitor Brain Activity in Real-world Cognitive Tasks
10:07

Using Fiberless, Wearable fNIRS to Monitor Brain Activity in Real-world Cognitive Tasks

Published on: December 2, 2015

28.1K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K

Related Experiment Videos

Last Updated: Mar 31, 2026

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
15:57

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

17.3K
Using Fiberless, Wearable fNIRS to Monitor Brain Activity in Real-world Cognitive Tasks
10:07

Using Fiberless, Wearable fNIRS to Monitor Brain Activity in Real-world Cognitive Tasks

Published on: December 2, 2015

28.1K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Memory dysfunction is a key aspect of age-related cognitive decline.
  • The prefrontal cortex plays a vital role in maintaining memory functions.
  • Understanding age-related changes in brain activity is crucial for cognitive health.

Purpose of the Study:

  • To investigate age-related alterations in prefrontal cortex oxygenation during memory encoding and retrieval.
  • To utilize near-infrared spectroscopy (NIRS) to measure cerebral blood flow changes.
  • To correlate prefrontal oxygenation levels with memory task performance across different age groups.

Main Methods:

  • Near-infrared spectroscopy (NIRS) was employed to measure oxyhemoglobin concentrations in the prefrontal cortex.
  • Participants included three groups: young (24.3 years), young-old (69.7 years), and old-old (79.5 years).
  • Memory performance was assessed by the number of correctly recalled words after a delay.

Main Results:

  • Reduced bilateral prefrontal oxyhemoglobin levels were observed in young-old and old-old groups during memory encoding compared to young adults.
  • During memory retrieval, only the old-old group exhibited significantly lower oxyhemoglobin levels compared to younger participants.
  • The old-old group demonstrated poorer memory retrieval performance, recalling fewer words than the young and young-old groups.

Conclusions:

  • Older adults (old-old) show diminished prefrontal oxygenation during both memory encoding and retrieval, correlating with decreased memory performance.
  • These findings highlight the impact of aging on prefrontal cortex function and its role in memory.
  • Clinical applications of NIRS require consideration of demographic factors, such as age, on cerebral oxygenation measurements.