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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Increased arterial inflammation in individuals with stage 3 chronic kidney disease

Richard A P Takx1,2, Megan H MacNabb1, Hamed Emami1

  • 1Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

European Journal of Nuclear Medicine and Molecular Imaging
|October 15, 2015
PubMed

Insights

Patients with chronic kidney disease (CKD) exhibit increased arterial inflammation, even in mild stages. This inflammation is linked to reduced kidney function and occurs independently of atherosclerosis, suggesting current risk assessments may be insufficient.

Area of Science:

  • Cardiovascular Imaging
  • Nephrology
  • Radiology

Background:

  • Chronic kidney disease (CKD) is a known risk factor for atherosclerosis.
  • The relationship between mild CKD and arterial inflammation remains unclear.
  • 18F-FDG PET/CT is a valuable tool for assessing arterial inflammation.

Purpose of the Study:

  • To compare arterial inflammation in patients with mild CKD versus matched controls.
  • To investigate the association between arterial inflammation and estimated glomerular filtration rate (eGFR).
  • To determine if arterial inflammation in CKD is independent of coronary artery calcification (CAC).

Main Methods:

  • A retrospective study of 128 patients (64 with stage 3 CKD, 64 controls) undergoing 18F-FDG PET/CT.
  • Arterial inflammation measured by 18F-FDG uptake in the ascending aorta.
  • Coronary artery calcification (CAC) assessed via CT imaging.
  • Analysis adjusted for background uptake and clinical risk factors.

Main Results:

  • Arterial inflammation was significantly higher in CKD patients compared to controls (SUV: 2.41 ± 0.49 vs. 2.16 ± 0.43, p=0.002).
  • Arterial inflammation correlated inversely with eGFR (r=-0.299, p=0.001).
  • Increased arterial inflammation in CKD was independent of CAC and clinical risk factors.

Conclusions:

  • Moderate CKD is associated with elevated arterial inflammation.
  • This inflammation is independent of subclinical atherosclerosis (CAC).
  • Current cardiovascular risk stratification may underestimate atherosclerosis risk in CKD patients.
Abstract

Keywords:
AtherosclerosisChronic kidney diseaseFDG PET/CTInflammation

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