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Developments in coupled solid-phase extraction-capillary electrophoresis 2013-2015.

Rawi Ramautar1, Govert W Somsen2, Gerhardus J de Jong3

  • 1Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

Electrophoresis
|October 15, 2015
PubMed
Summary

This review covers recent advancements in coupled solid-phase extraction-capillary electrophoresis (SPE-CE) systems from 2013-2015. It highlights new applications and techniques for improved sample analysis in various fields.

Keywords:
Biomedical and pharmaceutical applicationsEnvironmental and food applicationsIn-line SPE-CEMonolithsOn-line SPE-CE

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Area of Science:

  • Analytical Chemistry
  • Separation Science

Background:

  • This paper reviews coupled solid-phase extraction-capillary electrophoresis (SPE-CE) systems.
  • It continues previous reviews covering 2000-2013.

Purpose of the Study:

  • To provide an overview of SPE-CE system design and applications from July 2013 to June 2015.
  • To outline recent advancements and new interfacing techniques.
  • To demonstrate the applicability of SPE-CE in diverse studies.

Main Methods:

  • Literature review of SPE-CE systems.
  • Focus on in-line and on-line SPE-CE approaches.
  • Analysis of recent advancements like aptamer use and bead string designs.

Main Results:

  • Recent advancements include aptamers as affinity materials and bead string designs for fritless SPE-CE.
  • New interfacing techniques for on-line SPE-CE coupling were developed.
  • SPE-CE systems show broad applicability in biomedical, pharmaceutical, environmental, and food analysis.

Conclusions:

  • Coupled SPE-CE systems continue to evolve with innovative designs and applications.
  • The review provides a comprehensive table of recent SPE-CE studies, including sample types, sorbents, coupling, detection, and limits of detection (LOD).
  • Future perspectives on SPE-CE technology are discussed.