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Maltodextrin Acceptance and Preference in Eight Mouse Strains.

Rachel L Poole1, Tiffany R Aleman2, Hillary T Ellis2

  • 1Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA rpoole@monell.org.

Chemical Senses
|October 15, 2015
PubMed
Summary
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Genetics of mouse behavioral and peripheral neural responses to sucrose.

Mammalian genome : official journal of the International Mammalian Genome Society·2021

Mice show varied responses to maltodextrins, with CAST and PWK strains exhibiting lower preference compared to sucrose. This genetic variation in maltodextrin perception is key to identifying genes responsible for taste preferences.

Area of Science:

  • Genetics
  • Neuroscience
  • Animal Behavior

Background:

  • Rodents exhibit a strong attraction to maltodextrins.
  • Identifying genetic factors influencing taste perception requires understanding phenotypic differences across mouse strains.

Purpose of the Study:

  • To survey maltodextrin (Maltrin M040) avidity in eight inbred mouse strains.
  • To identify strain-specific variations in maltodextrin perception distinct from sucrose perception.

Main Methods:

  • Utilized 5-second brief-access tests to measure immediate licking responses.
  • Employed 48-hour two-bottle choice tests to assess long-term fluid intake and preference.
  • Tested eight inbred mouse strains: 129S1/SvImJ, A/J, CAST/EiJ, C57BL/6J, NOD/ShiLTJ, NZO/HlLtJ, PWK/PhJ, and WSB/EiJ.
Keywords:
2-bottle choice testCollaborative Crossbrief-access testsgustometermaltodextrin

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Main Results:

  • CAST and PWK strains showed significantly less licking of maltodextrin compared to sucrose in brief-access tests.
  • In two-bottle choice tests, CAST and PWK strains consumed less maltodextrin than sucrose, unlike other strains.
  • Strain variation in maltodextrin perception was observed, independent of sucrose perception.

Conclusions:

  • Phenotypic variation in maltodextrin acceptance has been identified across different mouse strains.
  • This variation provides a foundation for discovering genes that control maltodextrin preference.
  • Crosses such as C57 × PWK or NZO × CAST are recommended for identifying quantitative trait loci (QTLs) for maltodextrin acceptance.