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Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial

Huda Marzouk1, Hala M Lotfy1, Yomna Farag1

  • 1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.

International Journal of Chronic Diseases
|October 15, 2015
PubMed

Insights

Mean platelet volume (MPV) and splenomegaly can indicate subclinical inflammation in children with familial Mediterranean fever (FMF) during remission. Elevated MPV correlates with spleen size, suggesting their use as inflammatory markers.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Hematology

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease.
  • Identifying subclinical inflammation during attack-free periods is crucial for FMF management.
  • Mean platelet volume (MPV) and splenomegaly are potential, non-invasive inflammatory markers.

Purpose of the Study:

  • To investigate if mean platelet volume (MPV) and splenomegaly serve as subclinical inflammatory markers in pediatric FMF patients during remission.
  • To assess the correlation between MPV, spleen size, and inflammatory status in FMF.

Main Methods:

  • A cohort of ninety-seven children diagnosed with FMF was studied.
  • Mean platelet volume (MPV) was measured within 4 hours of blood collection.
  • Splenomegaly was assessed using abdominal ultrasound (USG).

Main Results:

  • Elevated MPV was observed in 84.45% of the pediatric FMF patients.
  • MPV levels were significantly higher in FMF patients with splenomegaly compared to those without.
  • A statistically significant positive correlation was found between MPV and splenic span (P = 0.045).

Conclusions:

  • Elevated MPV and splenomegaly are valuable indicators of subclinical inflammation in pediatric FMF patients during attack-free periods.
  • MPV and splenomegaly can be utilized as accessible markers for monitoring FMF activity.
  • Further research can explore the therapeutic implications of these findings.

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