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Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise.
Amanda Zaleski1, Jeffrey Capizzi1, Kevin D Ballard2
1Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
Journal of Sports Medicine (Hindawi Publishing Corporation)
|October 15, 2015
Summary
Strenuous exercise elevates inflammatory markers, but statins may reduce this effect. Marathon runners on statins showed lower p-selectin levels post-race compared to controls, indicating reduced inflammation.
Area of Science:
- Exercise physiology
- Cardiovascular health
- Pharmacology
Background:
- Strenuous endurance exercise can increase inflammatory markers, potentially raising acute cardiovascular risk.
- Statins are cholesterol-lowering drugs that may possess anti-inflammatory properties.
Purpose of the Study:
- To investigate the effect of statin use on inflammatory marker p-selectin levels in marathon runners.
- To determine if statins mitigate the exercise-induced inflammatory response.
Main Methods:
- Serum p-selectin levels were measured in statin-treated runners and non-statin controls before, immediately after, and 24 hours after the 2011 Boston Marathon.
- Statistical analysis compared p-selectin increases between groups and correlated levels with LDL-C.
Main Results:
- The increase in p-selectin after the marathon was significantly lower in statin users compared to controls immediately after and 24 hours post-race.
- Low-density lipoprotein cholesterol (LDL-C) levels were positively correlated with p-selectin levels, suggesting a link between cholesterol and inflammation.
Conclusions:
- Statins effectively reduce the exercise-induced increase in p-selectin following marathon running.
- The inflammatory response to strenuous exercise, as measured by p-selectin, is associated with baseline LDL-C levels.
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