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Updated: Mar 31, 2026
Murine Model of Wound Healing
Published on: May 28, 2013
Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel
Dênia Amélia Novato Castelli Von Atzingen1, Adriana Rodrigues dos Anjos Mendonça2, Marcos Mesquita Filho2
1School of Medical Sciences, Universidade do Vale do Sapucaí, Pouso Alegre, MG, BR.
Purpose:
To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats.
Methods:
A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28.
Results:
On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21. Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28.
Conclusion:
The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.
