Related Experiment Video
Updated: Mar 31, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
Published on: March 31, 2016
Impact of membrane bistability on dynamical response of neuronal populations
Wei Wei1,2, Fred Wolf3, Xiao-Jing Wang1,2,4
1Center for Neural Science, New York University, New York, New York 10003, USA.
Abstract:
Neurons in many brain areas can develop a pronounced depolarized state of membrane potential (up state) in addition to the normal hyperpolarized state near the resting potential. The influence of the up state on signal encoding, however, is not well investigated. Here we construct a one-dimensional bistable neuron model and calculate the linear dynamical response to noisy oscillatory inputs analytically. We find that with the appearance of an up state, the transmission function is enhanced by the emergence of a local maximum at some optimal frequency and the phase lag relative to the input signal is reduced. We characterize the dependence of the enhancement of frequency response on intrinsic dynamics and on the occupancy of the up state.
More Related Videos
Related Concept Videos
Resting Potential Decay
At rest, the K+ is the main ion that moves across the membrane...
Mechanisms of Membrane-bending
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Resting Membrane Potential
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
The Resting Membrane Potential

