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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Drugs Affecting GI Tract Motility: Other Laxatives01:20

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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

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Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
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Childhood constipation: finally something is moving!

Ilan J N Koppen1,2, Carlo Di Lorenzo2, Miguel Saps2

  • 1a Department of Pediatric Gastroenterology and Nutrition , Emma Children's Hospital/Academic Medical Center , Amsterdam , The Netherlands.

Expert Review of Gastroenterology & Hepatology
|October 15, 2015
PubMed
Summary
This summary is machine-generated.

Recent advancements in pediatric constipation management include new diagnostic tools and treatments. Innovations in colonic and anorectal manometry, electrical stimulation, novel drugs, and surgical approaches are improving outcomes for children with defecation disorders.

Keywords:
anorectal manometrychildrencolonic manometryconstipationelectrical stimulationsacral neurostimulation

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Area of Science:

  • Pediatric Gastroenterology
  • Colorectal Surgery
  • Pediatric Urology

Background:

  • Childhood constipation is a prevalent issue impacting children's quality of life.
  • Current management strategies are evolving with new technological and therapeutic advancements.
  • Understanding functional defecation disorders in children requires updated diagnostic approaches.

Purpose of the Study:

  • To provide an update on novel diagnostic and therapeutic tools for childhood constipation.
  • To review recent innovations in colonic and anorectal manometry.
  • To discuss emerging pharmacological, non-pharmacological, and surgical interventions.

Main Methods:

  • Review of recent developments in colonic and anorectal manometry.
  • Analysis of innovative therapies including electrical stimulation and new drug targets.
  • Evaluation of new surgical approaches guided by manometric findings.
  • Assessment of non-pharmacological interventions like fiber and probiotics.

Main Results:

  • Innovations in manometry offer novel insights into pediatric functional defecation disorders.
  • Electrical stimulation and new pharmacological agents show promising therapeutic results.
  • Manometry-guided surgical interventions have improved patient outcomes.
  • Non-pharmacological approaches, including fiber and probiotics, are of significant interest.

Conclusions:

  • Recent advancements are poised to significantly alter the future management of pediatric constipation.
  • A multimodal approach integrating novel diagnostics and therapeutics is crucial for optimal outcomes.
  • Continued research into innovative treatments will further refine the care of children with defecation disorders.