The development of hypoxic tumor cell cytotoxic agents

A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers.

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Utilization of distillers dried grains with solubles and phytase in sow lactation diets to meet the phosphorus requirement of the sow and reduce fecal phosphorus concentration.

Journal of animal science·2007

Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function.

The Journal of biological chemistry·2000

Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.

Circulation research·2000

Parallel syntheses of disulfide inhibitors of the thioredoxin redox system as potential antitumor agents.

Anti-cancer drug design·2000

Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts.

Cardiovascular research·2000

The critical role of ceramide in mental health and psychiatric diseases.

Pharmacology & therapeutics·2026

Irisin upregulation as a contributory mechanism for the therapeutic benefits of SGLT-2 inhibitors.

Pharmacology & therapeutics·2026

Mathematical modeling of T cell exhaustion in the tumor microenvironment.

Pharmacology & therapeutics·2026

Inorganic nanomaterials activate the cGAS-STING pathway for tumor treatment.

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Biomarker-guided pharmacotherapy in cardiovascular-kidney-metabolic syndrome: A three-dimensional framework for precision drug selection and monitoring.

Pharmacology & therapeutics·2026

AI-assisted design of next-generation antibiotics against multidrug-resistant Staphylococcus aureus.

Pharmacology & therapeutics·2026

[Effect of ESR1 Somatic Mutations on SERM/SERD Binding: Insights from Molecular Docking and Molecular Dynamics Simulations].

Molekuliarnaia biologiia·2026

RASA2 Promotes Pancreatic Cancer Metastasis by Activating TGFβ-Dependent Non-canonical Hedgehog Signaling.

Cancer research·2026

BRIGHTLINE-1: When a Negative Trial Reveals Two Active Therapies.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

The pan-tumor landscape, allelic status, and genomic complexity of SMARCA4 alterations.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles.

Blood cancer discovery·2026

Impact of GAD-65 Antibody Detection on Antihyperglycemic Therapy in T2D.

Endocrine connections·2026

Related Experiment Videos

The development of hypoxic tumor cell cytotoxic agents

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A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers.

Utilization of distillers dried grains with solubles and phytase in sow lactation diets to meet the phosphorus requirement of the sow and reduce fecal phosphorus concentration.

Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function.

Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.

Parallel syntheses of disulfide inhibitors of the thioredoxin redox system as potential antitumor agents.

Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts.

The critical role of ceramide in mental health and psychiatric diseases.

Irisin upregulation as a contributory mechanism for the therapeutic benefits of SGLT-2 inhibitors.

Mathematical modeling of T cell exhaustion in the tumor microenvironment.

Inorganic nanomaterials activate the cGAS-STING pathway for tumor treatment.

Biomarker-guided pharmacotherapy in cardiovascular-kidney-metabolic syndrome: A three-dimensional framework for precision drug selection and monitoring.

AI-assisted design of next-generation antibiotics against multidrug-resistant Staphylococcus aureus.

[Effect of ESR1 Somatic Mutations on SERM/SERD Binding: Insights from Molecular Docking and Molecular Dynamics Simulations].

RASA2 Promotes Pancreatic Cancer Metastasis by Activating TGFβ-Dependent Non-canonical Hedgehog Signaling.

BRIGHTLINE-1: When a Negative Trial Reveals Two Active Therapies.

The pan-tumor landscape, allelic status, and genomic complexity of SMARCA4 alterations.

CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles.

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The development of hypoxic tumor cell cytotoxic agents

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