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Updated: Mar 31, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
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Published on: September 28, 2015

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Angiotensin-converting enzyme inhibitor-induced angioedema and hereditary angioedema: a comparison study of attack

Nicolas Javaud1, Stéphane Charpentier, Frédéric Lapostolle

  • 1Emergency Department, Angioedema Reference Center (CRéAk), Public Assistance Hospital of Paris, University Hospital of Jean Verdier, France.

Internal Medicine (Tokyo, Japan)
|October 16, 2015
PubMed

Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE.

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