Related Experiment Video
Updated: Mar 31, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
Malignant nephrosclerosis in a patient with familial Mediterranean fever
Masayuki Yamanouchi1, Yoshifumi Ubara, Aya Imafuku
1Nephrology Center, Toranomon Hospital, Japan.
Abstract:
A 37-year-old man was admitted to our hospital for an evaluation of renal dysfunction and hypertension. The C-reactive protein level was 6.0 mg/dL, and the serum renin activity was extremely high. A renal biopsy showed malignant nephrosclerosis-like lesions with an onion skin pattern. He had a history of recurrent abdominal pain associated with periodic fevers above 38 degrees that resolved within three days. A MEditerranean FeVer (MEFV) gene analysis revealed that he was homozygous for the E148Q polymorphism (exon 2) and heterozygous for the L110P polymorphism (exon 2). The present case demonstrates that persistent subclinical inflammation can lead to malignant nephrosclerosis in familial Mediterranean fever patients with this genotype.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Nephrons
Nephrotic Syndrome II : Assessment and Medical Management
Chronic Kidney Disease II: Clinical Manifestations
Nephrotic Syndrome III : Nursing Management
Rheumatic Heart Disease I: Introduction

