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Related Concept Videos

Apoptosis01:30

Apoptosis

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Overview of Cell Death01:30

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Related Experiment Video

Updated: Mar 31, 2026

Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites
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Relationship between Eimeria tenella development and host cell apoptosis in chickens.

Yan Zhang1, Ming-xue Zheng2, Zhi-yong Xu3

  • 1College of Animal Science and Technology, Shanxi Agricultural University, Taigu, 030801, China.

Poultry Science
|October 16, 2015
PubMed
Summary

Eimeria tenella manipulates host cell apoptosis in chickens, initially preventing it and later promoting it. Inhibiting apoptosis aids parasite development, offering insights into coccidiosis prevention and treatment.

Keywords:
Eimeria tenellaapoptosiscecal epithelial cellchick embryodevelopment

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Area of Science:

  • Poultry Science
  • Parasitology
  • Cell Biology

Background:

  • Coccidiosis, caused by Eimeria tenella, results in significant economic losses in the poultry industry.
  • Current prevention methods like anticoccidials and vaccination are costly.
  • Understanding the host-parasite interaction is crucial for developing effective control strategies.

Purpose of the Study:

  • To investigate the dynamic relationship between Eimeria tenella development and host cell apoptosis in chickens.
  • To provide a theoretical foundation for understanding Eimeria tenella's injury mechanisms.
  • To explore novel avenues for coccidiosis prevention and treatment.

Main Methods:

  • In vitro culture of chicken embryo cecal epithelial cells.
  • Flow cytometry and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick-end labeling assays.
  • Histopathological analysis and application of a caspase-9 inhibitor (Z-LEHD-FMK).

Main Results:

  • Eimeria tenella infection initially reduced host cell apoptosis but increased it significantly at later stages (24-120 h).
  • Inhibition of apoptosis using Z-LEHD-FMK decreased host cell DNA injury and apoptosis rates.
  • However, inhibiting apoptosis led to higher Eimeria tenella infection rates in host cells.

Conclusions:

  • Eimeria tenella exhibits a dual role in host cell apoptosis, suppressing it early and inducing it later.
  • Inhibiting host cell apoptosis benefits the intracellular development of Eimeria tenella.
  • Targeting apoptosis pathways presents a potential strategy for coccidiosis management.