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A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells
P I Fields1, E A Groisman, F Heffron
1Department of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
Science (New York, N.Y.)
|February 24, 1989
Abstract:
Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.