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Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen
G Davatelis1, S D Wolpe, B Sherry
1Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021.
Science (New York, N.Y.)
|February 24, 1989
Abstract:
Macrophage inflammatory protein-1 (MIP-1) produced a monophasic fever of rapid onset whose magnitude was equal to or greater than that of fevers produced with either recombinant human cachectin (or tumor necrosis factor) or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 was not inhibited by the cyclooxygenase inhibitor ibuprofen. Thus, MIP-1 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase inhibitors.