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Oxygen Delivering System III: Tracheostomy and T-piece01:23

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Updated: Mar 31, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
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Multibreath alveolar oxygen tension imaging.

Justin Clapp1, Hooman Hamedani1, Stephen Kadlecek1

  • 1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Magnetic Resonance in Medicine
|October 16, 2015
PubMed
Summary

A new multibreath hyperpolarized helium-3 MRI method improves regional alveolar oxygen tension (PA O2) measurements. This technique significantly reduces errors from gas-flow artifacts, enhancing accuracy in patients with lung disease.

Keywords:
COPDair trappingalveolar oxygen tensioncollateral ventilationdiffusionhyperpolarized magnetic resonance imagingmultibreathslow fillingsmoking

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Area of Science:

  • Medical Imaging
  • Pulmonary Medicine
  • Magnetic Resonance Imaging

Background:

  • Conventional single-breath alveolar oxygen tension (PA O2) measurements are prone to errors from intervoxel gas flow.
  • These artifacts are particularly problematic in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD).

Purpose of the Study:

  • To evaluate a multibreath hyperpolarized helium-3 (HP (3)He) MRI protocol for improved PA O2 measurement accuracy.
  • To reduce the influence of gas-flow artifacts on regional PA O2 quantification.

Main Methods:

  • Implemented both single-breath and multibreath PA O2 imaging schemes.
  • Studied seven human subjects: one healthy, three asymptomatic smokers, and three with COPD.
  • Compared the incidence and location of nonphysiologic PA O2 voxels between protocols.

Main Results:

  • The multibreath scheme yielded significantly fewer nonphysiologic PA O2 values (6.0%) compared to the single-breath scheme (13.7%) (P = 0.006).
  • Gas-flow artifacts present in single-breath imaging were mitigated by the multibreath approach.
  • Multibreath imaging enabled analysis of slow-filling lung regions.

Conclusions:

  • A multibreath HP (3)He MRI approach enhances the accuracy and completeness of noninvasive PA O2 measurements.
  • This method significantly reduces nonphysiologic values caused by intervoxel gas flow.
  • The findings support the use of multibreath imaging for more reliable PA O2 assessment in lung disease.