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Multilocus sequence types of invasive pneumococcal isolates from Danish infants (0-90 days) 2003-2013

Hans-Christian Slotved1, Tine Dalby2, Steen Hoffmann3

  • 1Neisseria and Streptococcus Reference Laboratory, Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark. hcs@ssi.dk.

BMC Research Notes
|October 16, 2015
PubMed

Insights

Multilocus sequence typing (MLST) of invasive pneumococcal disease (IPD) isolates in Danish infants revealed common European strains. The findings indicate that circulating Streptococcus pneumoniae clones in Denmark align with those found across Europe.

Area of Science:

  • Microbiology
  • Epidemiology
  • Vaccinology

Background:

  • The Danish childhood immunization program includes pneumococcal conjugate vaccine (PCV) since 2007, with PCV-13 replacing PCV-7 in 2010.
  • Vaccination coverage is approximately 90%, but infants under 90 days are not vaccinated.
  • This study focuses on invasive pneumococcal disease (IPD) in infants aged 0-90 days.

Purpose of the Study:

  • To determine the multilocus sequence typing (MLST) profiles of Streptococcus pneumoniae isolates causing IPD in Danish infants.
  • To compare these profiles with those found in other European countries.

Main Methods:

  • Analysis of 32 IPD isolates from Danish infants (0-90 days) collected between 2003 and 2013.
  • Multilocus sequence typing (MLST) was used to characterize the Streptococcus pneumoniae isolates.

Main Results:

  • Identified MLST profiles (sequence types, STs) were consistent with those previously reported in other European countries.
  • Specific clones identified included ST 306 (serotype 1), ST 180 (serotype 3), and ST 191 (serotype 7F).

Conclusions:

  • The distribution of ST profiles in Danish infant IPD isolates is similar to findings in other European studies.
  • The majority of identified STs in Denmark are also found in other European countries.
  • This suggests that the IPD isolates in Denmark originate from clones commonly circulating within Europe.
Abstract

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