Upper Gastrointestinal Bleeding in Chinese Children: A Multicenter 10-Year Retrospective Study

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Published on: February 28, 2025

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Yi Yu1, Baoxiang Wang2, Lan Yuan3

  • 1Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Clinical Pediatrics
|October 16, 2015
PubMed

Insights

In Chinese children, erosive gastritis and duodenal ulcers are common causes of upper gastrointestinal bleeding (UGIB). Endoscopic evaluation within 48 hours improves diagnosis of bleeding sources.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Endoscopy
  • Clinical Research

Background:

  • Upper gastrointestinal bleeding (UGIB) is a significant concern in pediatric populations.
  • Understanding the specific causes and diagnostic approaches in children is crucial for effective management.

Purpose of the Study:

  • To analyze the clinical and endoscopic features of UGIB in Chinese children.
  • To identify the primary causes of UGIB and their age-related prevalence.
  • To evaluate the impact of endoscopic timing on diagnostic yield.

Main Methods:

  • A 10-year retrospective study involving 1218 children diagnosed with UGIB.
  • Data collected from four tertiary referral centers in China.
  • Esophagogastroduodenoscopy (EGD) findings were analyzed.

Main Results:

  • The bleeding source was identified in 76.4% of cases.
  • Erosive gastritis (33.5%) and duodenal ulcers (23.2%) were the most frequent findings.
  • Erosive gastritis prevalence decreased with age, while duodenal ulcer prevalence increased.
  • EGD performed within 48 hours improved the detection rate of bleeding sources (80.6% vs. 67.9%).

Conclusions:

  • Erosive gastritis and duodenal ulcers are leading causes of UGIB in Chinese children, with age-dependent variations.
  • Timely endoscopic intervention (within 48 hours) enhances the diagnostic accuracy for UGIB in pediatric patients.

Keywords:
NSAIDschildrenesophagogastroduodenoscopyetiologyupper gastrointestinal bleeding

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