Sleep aspects on video-polysomnography in LRRK2 mutation carriers
Mickael Ehrminger1,2, Smaranda Leu-Semenescu2,3,4,5, Florence Cormier2,3,4,5
1Ecole Normale Supérieure, Paris, France.
Summary
Rapid eye movement sleep behavior disorder is absent in individuals with leucine-rich repeat kinase 2 mutations, unlike in idiopathic Parkinson's disease (PD). This study clarifies sleep differences in genetic Parkinson's disease.
Area of Science:
- Neurology
- Sleep Medicine
- Genetics
Background:
- Rapid eye movement sleep behavior disorder (RBD) and sleepiness are common in idiopathic Parkinson's disease (PD).
- The presence of these sleep disturbances in individuals with leucine-rich repeat kinase 2 (LRRK2) mutations was previously unknown.
Purpose of the Study:
- To investigate the sleep phenotype, specifically RBD, in patients with LRRK2-associated PD.
- To compare the sleep characteristics of LRRK2-PD patients with idiopathic PD and healthy controls.
Main Methods:
- Clinical assessments and nighttime video-polysomnography were performed.
- Participants included patients with LRRK2-associated PD, idiopathic PD, healthy LRRK2 mutation carriers, and healthy controls.
Main Results:
- No significant sleep changes, including RBD or REM sleep without atonia, were observed in subjects with LRRK2 mutations compared to controls.
- 41% of idiopathic PD patients exhibited RBD, while 20% of LRRK2-associated PD patients showed abnormal periodic leg movements, similar to the idiopathic PD group.
Conclusions:
- The sleep phenotype in LRRK2-associated PD differs from idiopathic PD, notably with the absence of RBD.
- This suggests a distinct sleep profile for LRRK2-related Parkinson's disease across presymptomatic and symptomatic stages.
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