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Feedback Inhibition

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!

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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.

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Because many receptor binding ligands are hydrophilic, they do not cross the cell membrane and thus their message must be relayed to a second messenger on the inside. There are several second messenger pathways, each with their own way of relaying information. G-protein coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol path is active when the receptor induces phospholipase C to hydrolyze the phospholipid,...

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Related Experiment Video

Updated: Mar 31, 2026

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

The authors reply

Marc Ghannoum¹, Diane P Calello, Valéry Lavergne

¹Department of Nephrology, Verdun Hospital, University of Montreal, Verdun, QC, Canada Department of Emergency Medicine, Medical Toxicology Service, Morristown Medical Center, Morristown, NJ Department of Medical Biology, Sacré-Coeur Hospital, University of Montreal, Montreal, QC, Canada Department of Emergency Medicine, Medical Toxicology, Consultation Service, McGill University Health Centre, Montreal, QC, Canada Division of Nephrology, Department of Medicine, University of California, San Francisco, CA Burns, Trauma and Critical Care Research Centre, School of Medicine, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.

Critical Care Medicine

|October 16, 2015

Summary

No abstract available in PubMed .

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