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Clinical experience with ciprofloxacin: analysis of a multicenter study
Alabama Medicine : Journal of the Medical Association of the State of Alabama
|February 1, 1989
Summary
Ciprofloxacin demonstrated high efficacy in treating various infections, achieving clinical cure or improvement in 93.8% of patients. Adverse reactions were infrequent and generally mild, with low discontinuation rates.
Area of Science:
- Infectious Diseases
- Pharmacology
Background:
- Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic.
- Bacterial infections require effective and safe treatment options.
Purpose of the Study:
- To evaluate the efficacy and safety of ciprofloxacin in treating a variety of infections.
- To assess bacteriologic and clinical outcomes, as well as adverse drug reactions.
Main Methods:
- A multicenter study involving 128 patients treated with ciprofloxacin.
- Dosage: mean 982 mg/day; Duration: mean 8.9 days.
- Infections included microbiologically proven and chronic cases.
Main Results:
- 93% bacteriologic cure/improvement in microbiologically proven infections.
- 93.8% clinical cure/improvement in all 128 infections.
- Low incidence of adverse drug reactions (2.3%), with no definite relation to ciprofloxacin.
Conclusions:
- Ciprofloxacin is highly effective for treating diverse infections.
- The antibiotic exhibits a favorable safety profile with minimal adverse effects.
- Low rates of treatment discontinuation due to adverse gastrointestinal effects were observed.