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Updated: Mar 31, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Characterization of naproxen-polymer conjugates for drug-delivery
Gianpiero Forte1, Isabella Chiarotto1, Ilaria Giannicchi2
1a Dipartimento di Scienze di Base e Applicate per l'Ingegneria , Sapienza Università di Roma , Roma , Italy.
Abstract:
The synthesis and the characterization of three new naproxen decorated polymers are described. A versatile and general approach is employed to link the drug to polymers, affording the derivatives with a very high degree of purity. The release of the drug from the conjugates proved to be exceptionally slow, even in acidic aqueous media, and the kinetic of the process seems to be triggered by their solubility in water. On the other hand, the interesting outcome of the first ex vivo drug release experiments on human blood samples makes this preliminary study valuable for future investigations on the use of these polymeric prodrugs in in vivo treatment of inflammatory states.
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