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Area of Science:

  • Gastroenterology
  • Experimental Surgery
  • Toxicology

Background:

  • Corrosive esophagitis presents significant clinical challenges.
  • Existing experimental models for esophageal burns have limitations.

Purpose of the Study:

  • To develop and describe a new experimental model for inducing corrosive esophagitis in rats.
  • The primary goal was to create a model that prevents tracheal aspiration during the injury induction process.

Main Methods:

  • 16 Wistar albino rats were divided into a model group (n=8) and a control group (n=8).
  • A surgical procedure involved isolating an esophageal segment, which was then exposed to 10% NaOH (model group) or saline (control group) for 20 seconds.
  • Histopathological analysis was performed 10 days post-induction.

Main Results:

  • The model group exhibited significant histopathological changes, including submucosal collagen increase, damage to the muscularis mucosa and tunica muscularis, high neutrophil infiltration, tissue damage, and necrosis.
  • The control group showed minimal to no tissue damage, with no observed fibrosis.

Conclusions:

  • The developed model is effective in inducing localized corrosive esophagitis.
  • This less invasive and easily applicable method allows for targeted esophageal injury and facilitates subsequent administration of treatment medications.